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Special Report: Serotonin Precursors and Reuptake Inhibitors in Depressive Illness, by Ward Dean, M.D. and Steven Wm. Fowkes (the science and politics of serotonin, the pharmacology of reuptake inhibitors, the tryptophan/5-HTP alternative, and combination therapies); Serotonin Biosynthesis (a figure); Synthesis, Regulation and Uptake of Serotonin (a figure); Serotonin Flow Diagrams (a figure); Q&A (My physician will not support piracetam. The problems from L-tryptophan. What is the proper pronunciation of piracetam? Is dehydroascorbate really that toxic? How are liquid vitamin C products stabilized? Tourettes syndrome report.); The Oxidation and catabolism of Vitamin C (a figure); Recycling Pathways for Vitamin C (a figure); The Oxidation Dynamic Between Iron and Vitamin C (a figure); Smart Drug Update: Eleutherococcus Senticosus (Part 2), by Gavin Lee (metabolic effects, Soviet use and clinical trials of this adaptogen); Mice Performance (an illustration); Mice Survival (a figure); A Guide to Quality ES Products (a sidebar); New Practitioners (3); New Sources (3); Testing Services (1).
Smart Drug Update: Russian Adaptogens in Space, by Gavin Lee (the use of adaptogens in the Russian/Soviet space program and their applications to NASA); Scopolamine (a sidebar); Time in Space (a sidebar); Q&A (A traumatic head injury report. Who came up with dopa name? Would you better explain the use of predigested collagen for stroke victims? Is the scary stuff about aspartame and phenylalanine something to be concerned about? Problems with Skouvara? Liquid deprenyl available abroad? Liquid deprenyl for Parkinsons disease. CNN Impact said there was a documented death from GHB. CNN working on a smart-drug story. Can tryptophan or 5-HTP contribute to serotonin syndrome? What is the appropriate amount of choline to take with piracetam? Is high barium in a hair analysis reliable? Can I be chelated for barium poisoning? Does piracetam inhibit the passage of tyrosine into the cells? Flax oil safety?); Multistep Synthesis of Collagen Protein (a figure); Expanded view of Glycosylated Collagen Helix (a figure); Book Review: Natural Hormone Replacement Therapy, review by Anna C. Boroughs (a review of Natural Hormone Replacement Therapy for Women over 45, by Jonathan V. Wright, M.D. and John Morgenthaler); New Personnel at CERI (a sidebar); Media Renews Interest in Smart Drugs (a sidebar); New Practitioner (1).
Political Update and Editorial: FDA Commits to Codex Harmonization, by Steven Wm. Fowkes (all about this new international threat to health freedom); Congressional Bills Authorize Codex Harmonization (a sidebar about the fast tracking of bills through the House and Senate without debate). Q&A (Have vitamin B-6 supplements been turned into prescription drugs in England? Can we use piracetam with choline for our mildly autistic daughter? Do you know of physicians in the Washington area? Are you aware of any problems taking NADH and deprenyl citrate in the same program? What do you think of the DHEA-is-dangerous and DHEA-causes-cancer controversies? What tests should I take before starting DHEA? Do you know any London doctors who are optimistic about TNI for Downs syndrome? My wife is uncomfortable about the use of piracetam, and I am concerned about waiting. Can you point me to negative information about piracetam? Do you agree with Dr. Andrew Weils recommendation not to take vitamin C when you have iron toxicity? How can I find out whether my piracetam from Quotaz is genuine? My urine pH is always acid and nothing I do seems to change it.); The Steroid Tree (an illustration); Memory Regulator Found Links to Marijuana (a sidebar about anandamide and 2-arachidonylglycerol inhibition of memory); New Practitioners (2).
Program Update: Strategies for Parkinsons Disease Therapy, by Annetta Freeman with Anne Fowkes (an update on Annettas Parkinson disease program); Annetta Freemans Updated Personal Regimen (a sidebar listing the elements of her program); Smart Life Update: The Missing Method, by John Morgenthaler (using the ThinkFast computer program to measure ones cognitive abilities and evaluate ones smart-drug program); Fun and Games with Cognitive Testing (a sidebar on the use of games in cognitive assessment); Playing the Learning Curve (a sidebar on the statistical validity of testing systems); Q&A (Report on GHB use for depression. Is my present dosage of DHEA and pregnenolone advisable? Report on piracetam and verbalization in a teenager. Can you comment on the toxicity of MTBE gasoline additive? (3 illustrations). Can you suggest strategies for reducing winter colds? Report on detention and release of personal-use shipment. A report drawing attention to non-serotonin-based depression and the questioned utility of phenylalanine and tyrosine. Can you recommend fresh periwinkle as a source for vincamine?); Economic Savings from Piracetam Use (a sidebar on the financial savings in nursing costs when using piracetam with elderly disabled patients); Interlab Lawyer Defends Deprenyl (a sidebar about a letter-to-the-Editor from Interlabs lawyer complaining about our comments on European deprenyl); New Source (1); A New Year, A New Name (a sidebar announcing the renaming of the newsletter).
Smart Life Update and Book Review: Insulin Resistance, by Steven Wm. Fowkes (hyperinsulinemia and insulin resistance as a major facet of the aging process undermining cellular energy production and inducing obesity and degenerative disease how to reverse insulin resistance and lose body fat); Glucose Absorption Schematic (illustration); Age-Associated Insulinemia Trend (graph); Age-Related Changes in Insulin Response to Glucose Challenge (graph); hydroxybutyrate molecular diagrams (margin illustration); Carbohydrate Intake vs Energy Schematic (graph); Theoretical Optimization of Opposing Risk-Benefit Curves (graph); Viagra and NO Enhancers: A Concern? (a sidebar about potential synergy between arginine, Viagra, Ginkgo biloba and vinpocetine); Q&A: (What is RenewTrient? (3 illustrations) Prozac for Downs syndrome? (4 illustrations) What are the best smart drugs? Alzheimers treatments); Search Warrants Served on B&B Freight Forwarding (sidebar about legal problems of a deprenyl supplier).
Book Review and Smart Life Update: Tryptophan, 5-HTP and Serotonin, by Steven Wm. Fowkes (an extensive review of two books about serotonin precursors and serotonin drugs); Q&A: (Are there downside risks to androstenedione? (with 1 illustration) New Liquid Deprenyl Sources? Prozac as a therapy for constipation in Downs syndrome? (2 illustrations) Tobacco addiction vs carbohydrate addiction? Letter of detention from the FDA. What are the symptoms of serotonin syndrome? Butyrolactone and GHB-kit suppliers arrested); Personal Program Update: The Obsession Substitution Method, by Anne M. Fowkes (dealing obsessively with dieting obsession); Sources Update: (Professional Compounding Pharmacy, Clyde Reynolds, M.D., and Biogenesis).
Smart Life Update: Food Allergy and Neurodegenerative Disease, by Steven Wm. Fowkes (research that indicates a causal connection between gluten/food allergy, diabetes and neurological illnesses); Celiac Antibodies in Neurological Patients (an illustration); Oxidative Stress in Children during Heart Surgery (a sidebar with disturbing implications for Downs syndrome); Q&A: (Has there been any new research on BHT? (2 references) Is antioxidant supplementation for Downs syndrome really that simple? (1 illustration and 1 table) Whats the best way to raise testosterone in a 58-year-old man? (1 illustration) Does MCT fat really help with weight loss? Might GABA have an adverse effect on muscle tone in Downs syndrome? Is peak X contamination in 5-HTP a cause for concern?); How well do you rank real-life risks? (a sidebar on popular-vs-scientific assessment of risks); Smart Life Update: The Emergence of GHB Alternatives, by Steven Wm. Fowkes (GHB prohibition is driving consumers to butyrolactone and butanediol a comparison of pros and cons); GHB Precursors and Metabolites (an illustration).
Parkinsons Disease Update: Starting a Parkinsons Program, by Annetta Freeman with Steven and Anne Fowkes (strategic issues for combining the basic elements of anti-Parkinson therapy); The Parkinson Pyramid (a sidebar illustrating layers of Parkinsonian therapy); Synergy between Viagra and NO Enhancers (a sidebar comparing the mechanism of action of Viagra and NO enhancers with that of Hydergine and caffeine); Q&A: (A connection between celiac disease and a childs autism, What alternatives are there to GHB kits? Can I simply dilute butyrolactone with water? My doctor has solved my estrogen problem with Arimidex. How does one best inhibit aromatase and 5-alpha-reductase to optimize testosterone? What about overseas companies on import alert? The FDA says I need a prescription and IND#, do I? What the story on dicalcium phosphate use in tablets? A report on pernicious anemia causing learning delays. Thanks for the DS info!); Fractionation (a sidebar on the purification of butyrolactone); Smart Life Update: Import Policy Strategies III, by Steven Wm. Fowkes (strategic and Constitutional issue regarding FDA detentions); FDA Ordered to Lift Import Ban on Cholesterol-Reducing Dietary Supplement (Federal judge decides that Chinese red yeast rice powder is a dietary supplement and FDA acted illegally to block imports).