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#41: June 3, 1996 (Volume 5, No. 1) 12 pages
(click for full-text PDF file)Smart Drugs & Down’s Syndrome (Part 3): Nutritional Intervention in Down’s Syndrome, by Steven Wm. Fowkes (methylation pathways, collagen expression, serotonin synthesis, ammonia detoxification, nutritional assessment and customized interventions); Figure 1: The SAM Cycle (illustration and sidebar); Figure 2: Flow Diagrams of the SAM Cycle (illustration); Smart Drug Update: Recent Developments with Deprenyl, by Ward Dean, M.D. and Steven Wm. Fowkes (controversy about deprenyl/dopa combination therapy, results of the long-term Parkinson’s Disease Research Group study, personal experiences of the authors, and interim recommendations); Figure 1: Parkinson’s Disease Survival Data (two graphs); Figure 2: A Death Window (non-linearity in mortality figures); Q&A: (Can I replace Prozac with tryptophan? Smart-drug synergy report. Can piracetam affect lipid metabolism? What are the side effects and cognitive improvements from piracetam? How much glucosamine should be taken for a herniated disk? How can I get back issues on Down’s syndrome and aspartame? Do smart drug dosages have to increase as we get older? Did you change the newsletter format?).
#42: August 1, 1996 (Volume 5, No. 2) 12 pages
(click for full-text PDF file)Research Update: Mitochondrial Nutrition, Aging and Cognition, by Ward Dean, M.D. and Steven Wm. Fowkes (the nutritional basis of energy production, applied to Parkinson’s disease, aging, and cognitive performance — all about ALC, coenzyme Q, coenzyme 1, lipoic acid and other nutrients); Figure 1: Mitochondrial Energy Production (illustration of the citric acid cycle and electron transport chain); Figure 2: Mitochondrial Energy Schematic (a battery-and-hydraulic analogy illustration); Figure 3: Structure of NAD and Proposed Neurotoxins (margin illustration); Figure 4: Parkinson’s Disease (nigral mitochondrial dysfunction chart); Mitochondria and AIDS (sidear about AZT toxicity); Mitochondrial Toxins (sidebar); Nutrition Update and Editorial: Vitamin C, RDAs and Politics, by Steven Wm. Fowkes (new research findings about optimal vitamin C intake expose decades of politics in setting RDAs); Figure A: Vitamin C Levels vs Dose in 7 Men (new findings from the National Institutes of Health); Figure B: Vitamin C Levels Comparison Chart (illustration of least vs highest response); Q&A: (Doctor comments on mycotoxins from toe nail fungus. Where can I get NADH? How can we prevent the hospital staff from taking away our vitamins? Report about ordering from several overseas sources. Report comparing the advantages and pitfalls between government mail and expedited freight for personal drug importations. Report on psychiatric mis-treatment of daughter.).
#43: September 2, 1996 (Volume 5, No. 3) 12 pages
(click for full-text PDF file)Nutrition Update: Mitochondria, Hypothyroidism and Weight Loss, by Steven Wm. Fowkes, Ward Dean, M.D. and Thomas H. Nufert (the link between thyroid hormone and mitochondrial function, and how this relates to biological energy production, the free radical defense system, caloric balance and weight loss); Figure 1: The Influence of Thyroid Hormones on Mitochondrial Energy Production (illustration); Figure 2: Basal metabolic Rate vs Age (from Biological Aging Measurement); Of Rats, Birds and Man (sidebar about mitochondrial lipid composition and species lifespan); Normal Healthy Human Studies: Stabilium and Anxiety, by Steven Wm. Fowkes (a nutrition therapy from neolithic times relieves anxiety in college students); Figure A: Stabilium vs Anxiety Scores (graph); Figure B: Volatility of Anxiety Test Scores (graph); Editorial and Opinion: The Biological Evolution of Energy Systems, by Steven Wm. Fowkes (entropy, evolution, energy systems and ecological catastrophes); Q&A: (How do I know which improvements relate to piracetam and which to Nutrivene? Would piracetam help a boy with ADD? Do you recommend attack doses of piracetam for children? What about other nootropics for Down’s syndrome therapy? At what age can children start piracetam? Report on successful treatment for Leigh’s disease. Comment and response about ketogenic diets. Can I use melatonin to increase glutathione peroxidase levels in my 3 year old with Down’s syndrome? How do I calculate dosing when using a liquid medication? How do I visit your web site?).
#44: October 23, 1996 (Volume 5, No. 4) 12 pages
(click for full-text PDF file)Nutrition Update: Tryptophan and Tourette’s Syndrome, by Steven Wm. Fowkes (a new study of identical twins localizes Tourette’s symptoms in the brain); Guest Editorial: The Health Interests of Millions are at Stake, an open letter by Matthias Rath, M.D. (Codex Commission plans to turn nutrients into drugs worldwide); Editorial: The Emerging Nutrition Paradigm in Medicine, by Steven Wm. Fowkes (social implications of a changing world view); Q&A: (What can you tell me about pyruvate dehydrogenase deficiency (with 2 illustrations)? How can I dose deprenyl corectly? Will piracetam, Hydergine or deprenyl show up on an employment drug test? What’s the best starting dose of Hydergine, piracetam and deprenyl, and which should I start first? Which smart drugs might help an essential tremor of the head? What are your thoughts about smart drugs for benign essential tremor (with illustration)? Report on Prozac and essential tremor. Report on sex-enhancing drugs. Comment on B12 and vaccination.); Smart Drug Update: Piracetam and High Altitude Stress, by Steven Wm. Fowkes and Ward Dean, M.D. (more about anti-hypoxic effects of piracetam).
#45: December 13, 1996 (Volume 5, No. 5) 12 pages
(click for full-text PDF file)Lifestyle Update: Living with Alcohol, by Steven Wm. Fowkes (the toxicology of alcohol and nutrients which prevent it); Figure A: Pathways for Alcohol metabolism (an illustration); Figure B: Molecular Structures (of glutathione, cysteine, thiamine and lipoic acid); My Experience with Alcohol (a sidebar by Anne Fowkes relating to alcohol and Parkinson’s disease); Q&A (Melatonin report. Where can I get generic deprenyl? Can I get DMAE without the bitartrate? Is what Macrobiotics Today says about deprenyl true? Do DHEA and pregnenolone cross the blood-brain barrier? Which smart drugs are best for young, healthy people? Where can I find vegetarian multi-vitamins? DMAE therapy for ADD and ADHD instead of Ritalin. Stabilium in the UK? Optimal melatonin dosage for sleep? Report of Parkinson’s regimen. Are ampakine memory-enhancing drugs available anywhere?); Editorial: Kessler’s Legacy to the FDA, by Steven Wm. Fowkes (overbilling scandal leads to Kessler’s resignation, but unconstitutional activities remain high priority at the agency).
#46: January 13, 1997 (Volume 5, No. 6) 12 pages
(click for full-text PDF file)Smart Drug Update: Introduction to Adaptogens (Part 1), by Gavin Lee (the key contrasts between Eastern and Western views of phytomedicines that enhance physical and mental performance and adaptive capacity); Figure A: 3-Dimensional Molecular Structures (of ephedrine and catecholamine derivatives); Left and Right Handed Molecules (a sidebar explaining stereochemistry); The Lock-and-Key Model (a sidebar explaining receptor-substrate affinity); Pharmacological Variation (a sidebar explaining potency, biological specificity, chemical specificity, and specific antagonists); Dose-Response Curves and Therapeutic Index); Drugs vs Substrates (a sidebar about confusion from ambiguity in English technical language); Q&A (A report about DMAE and studying. A vote against the FDA. Does dimethylglycine (DMG) enhance ATP? Can I get customized capsules made? Report of unusual reactions to Ginkgo. Report on “crunching” problem from pyroglutamate. Report that niacin helps memory. Report that oxiracetam better than piracetam.); Book Review: The Super Hormone Promise, by Thomas H. Nufert (a review of The Super Hormone Promise, by William Regelson, M.D. and Carol Colman).
#47: February 18, 1997 (Volume 5, No. 7) 12 pages
(click for full-text PDF file)Smart Drug Update: Introduction to Adaptogens (Part 2), by Gavin Lee (Eastern pharmacology, Russian adaptogens and the worldwide phytomedicine market); Known Adaptogens (a comprehensive table of adaptogens from around the world); Q&A (A deprenyl report. Successful therapy for an autism case. Is there an adverse effect of zinc on memory? Tea consumption reported to decrease thiamine and brain acetylcholine levels. Alcohol and cysteine report. How does alcohol increase body warmth?); Mitochondrial Respiratory Control States (a sidebar discussing rate-limiting factors for energy production and metabolic rate); Editorial: GHB Madness, by Ward Dean, M.D. and Steven Wm. Fowkes (the history, tactics and political motivations behind the FDA’s nationwide campaign to criminalize GHB on a state-by-state basis).
#48: March 21, 1997 (Volume 5, No. 8) 12 pages
(click for full-text PDF file)Smart Drug Update: Introduction to Adaptogens (Part 3), by Gavin Lee (a brief summary); In Search of a Designer Brain (Part 1), by Steven Wm. Fowkes (part 1 of a series examining neurotransmitter systems and neurotransmitter balance); Dosage Range Guide (to DMAE, choline, phosphatidylcholine and magnesium); Biosynthesis of Acetylcholine (a figure); Structural Components of Co-Enzyme A (a figure); Q&A (Are my vitamins dissolving? Is the aluminum in colloidal minerals safe? Smart-drug report. Can people take anti-anxiety medications with kava-kava? What is the best source for GHB and tryptophan? Down’s vs Down syndrome. Codex in Canada, US next? What precautions should be taken when giving piracetam to a child with seizures? Are there any nutrient-drug interactions with a child taking TNI? Is GHB soluble in water or alcohol? How can I split the dose in piracetam capsules? Is carbohydrate required to assimilate 5-HTP? What is your opinion about the dangers of 5-HTP as raised by Dr. Steven Harris? Is glutamate or glutamine preferred as a cognitive stimulant? Rights to pleasure and self discovery); New Practitioners (6).
#49: June 4, 1997 (Volume 5, No. 9) 12 pages
(click for full-text PDF file)Smart Drug Update: The Case for Piracetam in Down’s Dyndrome, by Steven Wm. Fowkes (a review of the Fiona study and recent research with direct or indirect relation to DS); The Fiona Study (a sidebar and illustration); Senility Prescription Practices (a sidebar); Piracetam and Sickle Cell Anemia (a sidebar, also on Angelman syndrome); Q&A (Where are these horrible rumors about GHB coming from? GHB in Italy. Can I make stable solution of vitamin C, B6 and phenylalanine? Is there a significant difference between potassium GHB and sodium GHB? Are GHB kits going to be legal? Do you know of any connection between hormone replacement therapy and Duputren’s contractures?); Letter to Customs (a sidebar with a sample letter asserting Constitutional rights to seized imported medications and holding the Department of the Treasury responsible for failure to release the shipment); Book Review: Brain Longevity, review by Anne M. Fowkes (a review of Brain Longevity: The Breakthrough Medical Program that Improves Your Mind and Memory, by Dharma Singh Khalsa, M.D. with Cameron Stauth); New Sources (4); New Practitioner (1).
#50: July 4, 1997 (Volume 5, No. 10) 12 pages
(click for full-text PDF file)Smart Drug Update: Eleutherococcus Senticosus (Part 1), by Gavin Lee (the discovery, development, pharmacology and toxicology of one of the most popular adaptogens); Eleutherococcus Regions of the World (an illustration); Eleutherococcus senticosus Maxim. (an illustration); Biologically Active Eleutherococcus Senticosus Glucosides (a figure); ES and Stress Reduction (a sidebar); Q&A (Dr. Henri Laborit was the discoverer of GHB. What does the pineal gland do? Report on QHI service. Down’s syndrome and doctors.); Nutrition Update: In Search of a Designer Brain (Part 2), by Steven Wm. Fowkes (the balance between serotonin and dopamine in the limbic system and how it affects the mind); Dopamine Biosynthesis (a figure); Serotonin Biosynthesis (a figure); A Hypothetical Brain Map (an illustration); Neurotransmitter Balance on Multiple Levels (an illustration); Compromised Neurotransmitter Balance between Misaligned Levels (an illustration); Dosage Range Guide (L-dopa, L-tryptophan and 5-hydroxy-L-tryptophan).