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#31: May 8, 1995 (Volume 4, No. 1) 12 pages
(click for full-text PDF file)Research Update (Part 1): Aspartame, by Mark D. Gold, Steven Wm. Fowkes and Ward Dean, M.D. (the biological/ cognitive effects of NutraSweet); Special Report Deprenyl Stories, by J. R. Richards (ten anecdotes about people using deprenyl); Figure 1: The Metabolism of Aspartame (three major pathways); Aspartame in Solution (sidebar on aspartame stability with long-term storage); Q&A (Do you know of a source for pemoline? Is there a treatment for Tourette’s syndrome? Report on Eldepryl and chorionic gonadotropin. Help for mental fatigue? Can you recommend cognitive enhancers that are similar to amphetamine? Report on tyrosine and ephedrine. Is dexfenfluramine or fenozolone compatible with deprenyl and/or Hydergine?); Book Review: Better Sex Through Chemistry, review by T. Michael Hardy; New Source (1).
#32: May 29, 1995 (Volume 4, No. 2) 12 pages
(click for full-text PDF file)Research Update (Part 2): Aspartame, by Mark D. Gold, Steven Wm. Fowkes and Ward Dean, M.D. (the effects of NutraSweet on various disorders and the scientific irregularities in research submitted for its approval); Book Review: Nature’s Sleeping Pill, review by T. Michael Hardy (Nature’s Sleeping Pill, by Ray Sahelian, M.D.); The Mysterious Disappearing/Reappearing Aspartame Data (sidebar on brain tumor slides that changes sides); Temperature Stability of Aspartame (sidebar); Q&A (CERI’s e-mail addresses. Report on detained order from B. Mougios. Can you direct me to John R. Lee, M.D. and Ray Peat, Ph.D.? Report on impotence problem connected to aspartame use. How much liquid DHEA should I use? Report on Interlab quality control problem with deprenyl. How to order liquid deprenyl from B&B Freight Forwarding. Is the Q&A column the only way to get questions answered? Is there an added charge for overseas delivery of back issues? What are recommended dosages of DHEA and blood levels of DHEA-S? Report on smart-drug program. Should I avoid aspartate and phenylalanine dietary supplements? Should I be alarmed about the high aspartate and glutamate on food labels? A letter to ASTAK.); Does Melatonin Defend DNA from Radiation Damage? by Ray Sahelian, M.D. (sidebar with illustration); Sources Update (Sandoz discontinues Diapid, Masters and credit cards, ALP adds GHB and smart drugs); New Practitioners (3), New Sources (2).
#33: July 10, 1995 (Volume 4, No. 3) 8 pages
(click for full-text PDF file)Nutrition Update: Tryptophan Aggression and Mood, by Ray Sahelian, M.D. (tryptophan intake vs aggression, violence may have nutritive roots); Speculations About Subclinical Deficiencies? (sidebar about family violence and “rednecks”); Q&A (Why don’t you list Mexican pharmacies on your sources listing? Is there a connection between deprenyl and DMAE sensitivity? How about a composite smart-drug formula? Extensive report on tyrosine’s and phenylalanine’s effects. What are the advantages/disadvantages of generic and non-generic forms of Hydergine? Which suppliers will ship to Japan? Are smart drugs helpful for yoga and meditation? Where should we send questions? Can I protect myself from aspartame?); A Concern About Deprenyl Stockpiling (sidebar about the politics and legalities related to deprenyl); Welcome Dr. Ray Sahelian (Ray Sahelian joins CERI and Medical Advisor to Smart Drug News); How to Reach Us on the Internet (and Web Site Coming); New Practitioners (2); New Source (1).
#34: August 11, 1995 (Volume 4, No. 4) 12 pages
(click for full-text PDF file)Starting a Smart-Drug Program (Part 1): The Smart Drug Pyramid, by Steven Wm. Fowkes (the first of a multi-part series on the basics of using smart drugs and nutrients); An Open Letter to FDA Commissioner Kessler: FDA Wants DHEA Scheduled, by Steven Wm. Fowkes (Is the FDA pressuring the DEA to schedule DHEA to avoid Congressional restrictions?); Nutrition Update: Don’t Blame the Burrito, by Ray Sahelian, M.D. (recent research on the effect of caffeine on sleep); Sources Update (PBRV ceases operations); Q&A (could tryptophan function like Prozac or other SSRIs against depression? Do melatonin and imipramine interact? Report on smart-drug program. Can you see anything in my pH charts which might explain my extreme tiredness and cognitive problems? [with two illustrations] Science News fails to mention Richard Wurtman’s conflict of interest regarding melatonin. Do you have suggestions for my slow-moving son? How does supplemental phenylalanine compare to aspartame-derived phenylalanine? Should I be concerned about protein powder that contains di- and tripeptides? Report on negative reaction to deprenyl. Do US pharmacies really carry piracetam? Which overseas company should I do business with and should I place smaller, more frequent orders?); Political Update: Health Freedom Bill Reintroduced, by Steven Wm. Fowkes (HR 1951 to put “teeth” back into dietary supplement reform); Book Review: Receptors, review by T. Michael Hardy (Receptors, by Richard M. Restak, M.D.); New Sources (5).
#35: October 1, 1995 (Volume 4, No. 5) 12 pages
(click for full-text PDF file)Starting a Smart-Drug Program (Part 2): Basic and Optimum Nutrition, by Steven Wm. Fowkes (the basic role of nutrition in brain function); Figure 1: Effect of Intake Frequency on Nutrient Availability (illustration); Figure 2: Production of Energy and Reducing Power (illustration); Book Review: Talking Back to Prozac, review by T. Michael Hardy (Talking Back to Prozac, by Peter R. Breggin, MD and Ginger Ross Breggin); Nutrition Update: DHEA Capsules vs Liquid DHEA, by Steven Wm. Fowkes and Ward Dean, M.D. (two short-term studies show conflicting results); Sources Update: Controlled Substances, by T. Michael Hardy (a pitfall and warning to those ordering from overseas); Nutrition Update: Melatonin and Heart Disease, by Ray Sahelian, M.D. (is there a connection between melatonin and autonomic activation?); Autonomic nervous Functions (a sidebar presenting sympathetic and parasympathetic influences); Q&A (Why not try a high-tryptophan diet before trying SSRIs or tryptophan? Could my taking deprenyl affect any blood or urine tests? Confusion about normal urine pH readings [with illustration] while taking fermented Kombucha tea. Report of Canadian detention of smart drug order. Will you help with my InHome order? Does cystine markedly inhibit the thyroid gland’s function? Can Rogaine cause cognitive impairment? Are there any more sources for GHB? Can memory loss or other brain function impairment result from chemotherapy? Research on Hydergine equivocal? Report on Hydergine, choline and DMAE use.); The Future Includes Smart Drugs and Life Extension (a sidebar about the publication of Future in Sight, a book by Barry Minkin); Sources Update (PBRV is out of business, BIOS now accepts credit cards); New Source (1); CERI Web Site is Installed.
#36: November 6, 1995 (Volume 4, No. 6) 12 pages
(click for full-text PDF file)An Interview with Annetta Freeman: An Improved Parkinson’s Therapy, by Steven Wm. Fowkes (the use of Discovery liquid deprenyl and high-dose antioxidants for one woman’s partial remission); Starting a Smart-Drug Program (Part 3): Neurotransmission, by Steven Wm. Fowkes (the basic structure and organization of the brain into neurotransmitter systems and receptor subtypes); Annetta Freeman’s Personal Regimen; Editorial: Prescription Tryptophan Returns to US, by Steven Wm. Fowkes (compounding pharmacies stock tryptophan despite continuing FDA ban); Nerve Conduction Schematic (a figure); Book Review: The Melatonin Miracle, review by T. Michael Hardy (a review of Pierpaoli and Regelson’s book, The Melatonin Miracle); Smart Drug Update: New Developments with Modafinil, by Jorge Quiñónez (recent changes in modafinil’s status in France, Canada and the US); Trisomy 21 News Update: Down’s Syndrome Symposium, by Dixie Lawrence (upcoming conference and progress report); and New Source (1).
#37: November 28, 1995 (Volume 4, No. 7) 12 pages
(click for full-text PDF file)Starting a Smart-Drug Program (Part 4): Neurotransmitter Precursors, by Steven Wm. Fowkes (tryptophan, dopa, phenylalanine, tyrosine, choline, DMAE, phosphatidylcholine, GABA, GHB, aspartate, glutamate and glutamine are discussed); Analysis and Opinion: Intelligence Enhancement, by David Bezanson, Ph.D. (a discussion of the genetic, developmental and environmental influences on intelligence, and factors that can either enhance or encumber intelligence); Tryptophan Metabolism (a figure); New Source (1); Phenylalanine, Tyrosine and Dopa metabolism (a figure); Choline Metabolism (a figure); Metabolites of Glutamate (a figure); IQ Statistics (predictive validity and its effect on economic productivity); Meditation (a sidebar); Q&A (Something to help tinnitus? References for vasopressin use in elderly? New developments with BHT’s use for herpes? What can we try for my daughter’s ©atypical major depressionª? What’s new for my chronic sinusitis and bronchitis? What about brands and quality of cartilage products? Might vasopressin help with my father’s Parkinson’s disease?); Nutrition Update: Vitamins Can make You Happier, by Ray Sahelian, M.D. (recent study reports effects of nutrients on mood); Benton, Haller and Fordy Supplement Formula (a sidebar).
#38: January 24, 1996 (Volume 4, No. 8) 12 pages
(click for full-text PDF file)Book Review: Melatonin: The Best Book Yet, review by T. Michael Hardy (review of Reiter and Robinson’s Melatonin: Your Body’s Natural Wonder Drug); Editorial: The Efficacy Standard Reconsidered, by Steven Wm. Fowkes (the politics and corrupting influence of the efficacy standard, and it’s impact on public health); Personnel Changes at Smart Drug News (a sidebar); Sources Update (phony GHB, seizures in Atlanta, and a source for modafinil); Q&A (Advice or information? Any problems with Discovery of Mexico? Can I combine deprenyl with phenfluramine and phentermine? How do arginine- and lysine-vasopressin differ? What impact are FDA interceptions having on personal-use importations? Can I switch from benzodiazepines to buspirone? Can I take smart drugs with Moban and amantadine? Can I take deprenyl with Adipex? Is there anything that will help me regenerate spinal neurons after a broken neck injury? What can help with my anxiety? Why is the Discovery liquid deprenyl so much better than other brands? How long can PCA, DMAE (or Lucidryl) and piracetam be taken without losing their effect? What can be expected from their long-term usage? Would Lucidryl work better than DMAE? L-Tryptophan gave me a headache, could Wellbutrin have been responsible? What should I try with my 28-year-old son with learning difficulties? Will nutrients or nootropics help stop damage caused by multiple sclerosis and epilepsy? Does dampness affect the potency of GHB? What information can I give my doctor to convince him to prescribe GHB?); New Source (1); New Practitioners (2) (with addendums for Dr. Marcel Valer and Dr. Lord Lee-Benner); To Fax or to Phone? (sidebar on policy for getting questions answered); Another Editorial Opinion (Dr. Ray Sahelian comments on Steve Fowkes’ editorial); The Return of Thalidomide (sidebar accompanying editorial); Calendar of Upcoming Events.
#39: February 29, 1996 (Volume 4, No. 9) 12 pages
(click for full-text PDF file)Smart Drug Update: A Consumer’s Guide to Using Melatonin, by Steven Wm. Fowkes and Ray Sahelian, M.D. (how dosage and timing influences effectiveness of different melatonin supplements, including four illustrations); Lights Out for Melatonin in Canada (sidebar); Nutrition Arts (Part 1): The Art of Nutritional Therapeutics, by Thomas Nufert (general strategies for identifying and dealing with nutritional deficiencies, both primary/dietary and secondary/induced); Induced Vitamin C Deficiency (sidebar about sudden infant death syndrome); Zinc Caution (sidebar about using zinc during infection); Q&A (Is there a calcium problem with piracetam? Is piracetam excitotoxic? What are the long-term effects of taking deprenyl? Congratulations on your web site! Melatonin increased my sense of smell. Am I suppressing my melatonin production? Can I use yam products to increase my DHEA, or should I use real DHEA?); New Source (1); Calendar of Upcoming Events (4); Melatonin Sex Survey.
#40: April 15, 1996 (Volume 4, No. 10) 12 pages
(click for full-text PDF file)Smart Drugs & Down’s Syndrome (Part 2): Antioxidant Intervention in Down’s Syndrome, by Steven Wm. Fowkes (treatment strategies for ameliorating the oxidative stress caused by genetic overexpression of superoxide dismutase on the 21st chromosome, with 3 illustrations); Melatonin Update: Is Melatonin a Sex-Enhancing Hormone?, by Steven Wm. Fowkes (initial results of the Melatonin Sex Survey); What are Free Radicals (sidebar); The Recycling of Glutathione (sidebar); FDA Retaliation Getting Noticed (sidebar); GATT (and the World Trade Organization) vs Vitamin Supplements (sidebar); Q&A (What different kinds of GHB are there? How do I convert units in my DHEA tests to those in your book? Does Hydergine block adrenal function? What do you know about oxygen therapy? Are there nutritional approaches to treating advanced cataracts? Is there any pro- or antioxidant activity from GHB? Report on smart drug benefits from ALC. Where can I get high-dose DHEA capsules? What can I do to protect my red blood cells from damage?); New Practitioners (3); Calendar of Upcoming Events (4).